Stanislav Y. Shvartsman
Dynamics of living tissues
Stas Shvartsman was born in Odessa, Ukraine, and studied chemistry and engineering in Russia, Israel, and the US. His lab investigates how genomically encoded and self-organizing processes control development. The main themes of current research are 1) dynamics of signaling networks, 2) small cell clusters, and 3) quantitative biology of developmental abnormalities.
Protein kinases control essentially all cellular functions and are genetically deregulated in human diseases. The Shvartsman lab uses Drosophila as a powerful experimental system for dissecting signaling through the highly conserved ERK cascade. Recent results include new tools for optogenetic control of the ERK-dependent dynamics of single genes and gene networks.
Cell clusters with stable cytoplasmic bridges are thought to have provided one path to the emergence of multicellularity and are essential for the formation of eggs and sperm in present day animals. The Shvartsman lab uses live imaging experiments and dynamical systems theory to investigate the formation and function of germline cell clusters in Drosophila.
Developmental defects are one of the leading causes of childhood mortality and a major factor in the lives of affected individuals and their families. Focusing on abnormalities caused by deregulated RAS signaling, the Shvartsman lab is advancing quantitative biology of developmental disorders, using genome editing and computational modeling approaches in Drosophila.
The Shvartsman lab collaborates with scientists at Princeton and elsewhere and had in the past published on a broad range of topics, including epithelial morphogenesis, morphogen gradients, and metabolic control of development.
- 1.Huang S-K, Whitney P, Dutta S, Shvartsman S, Rushlow C. Spatial organization of transcribing loci during early genome activation in Drosophila. Curr Biol. 2021;31(22):5102–5110.e5. PMCID: PMC8612988
- 1.Marmion R, Yang L, Goyal Y, Jindal G, Wetzel J, Singh M, Schüpbach T, Shvartsman S. Molecular mechanisms underlying cellular effects of human MEK1 mutations. Mol Biol Cell. 2021;32(9):974–983. PMCID: PMC8108529
- 1.Fiore V, Krajnc M, Quiroz F, Levorse J, Pasolli A, Shvartsman S, Fuchs E. Mechanics of a multilayer epithelium instruct tumour architecture and function. Nature. 2020;585(7825):433–439. PMCID: PMC7787055
- 1.Fiore V, Krajnc M, Quiroz F, Levorse J, Pasolli A, Shvartsman S, Fuchs E. Publisher Correction: Mechanics of a multilayer epithelium instruct tumour architecture and function. Nature. 2020;586(7827):E9. PMID: 32913346
- 1.Yeung E, McFann S, Marsh L, Dufresne E, Filippi S, Harrington H, Shvartsman S, Wühr M. Inference of Multisite Phosphorylation Rate Constants and Their Modulation by Pathogenic Mutations. Curr Biol. 2020;30(5):877–882.e6. PMCID: PMC7085240
- 1.Taylor C, Cormier K, Keenan S, Earnest S, Stippec S, Wichaidit C, Juang Y-C, Wang J, Shvartsman S, Goldsmith E, Cobb M. Functional divergence caused by mutations in an energetic hotspot in ERK2. Proc Natl Acad Sci U S A. 2019;116(31):15514–15523. PMCID: PMC6681740
- 1.Jindal G, Goyal Y, Humphreys J, Yeung E, Tian K, Patterson V, He H, Burdine R, Goldsmith E, Shvartsman S. How activating mutations affect MEK1 regulation and function. J Biol Chem. 2017;292(46):18814–18820. PMCID: PMC5704466
- 1.Arora N, Alsous J, Guggenheim J, Mak M, Munera J, Wells J, Kamm R, Asada H, Shvartsman S, Griffith L. A process engineering approach to increase organoid yield. Development. 2017;144(6):1128–1136. PMCID: PMC5358111
- 1.Goyal Y, Jindal G, Pelliccia J, Yamaya K, Yeung E, Futran A, Burdine R, Schüpbach T, Shvartsman S. Divergent effects of intrinsically active MEK variants on developmental Ras signaling. Nat Genet. 2017;49(3):465–469. PMCID: PMC5621734
- 1.Goyal Y, Levario T, Mattingly H, Holmes S, Shvartsman S, Lu H. Parallel imaging of embryos for quantitative analysis of genetic perturbations of the Ras pathway. Dis Model Mech. 2017;10(7):923–929. PMCID: PMC5536913
- 1.Jindal G, Goyal Y, Yamaya K, Futran A, Kountouridis I, Balgobin C, Schüpbach T, Burdine R, Shvartsman S. In vivo severity ranking of Ras pathway mutations associated with developmental disorders. Proc Natl Acad Sci U S A. 2017;114(3):510–515. PMCID: PMC5255624
- 1.Cardoso M, Fontenele M, Lim B, Bisch P, Shvartsman S, Araujo H. A novel function for the IκB inhibitor Cactus in promoting Dorsal nuclear localization and activity in the embryo. Development. 2017;144(16):2907–2913. PMCID: PMC5592809