Research in the McBride lab takes advantage of evolution in natural populations to understand the genomic and neuronal basis of behavior and the mechanisms by which behaviors evolve. We are an interdisciplinary group with joint membership in the Princeton Neuroscience Institute and the Department of Ecology and Evolutionary Biology. We therefore approach our research from multiple perspectives, including evolution, neuroscience, and public health. Methodologically, our work combines evolutionary genomics with field work, molecular genetics, electrophysiology, and neural imaging. Please click on the links to the left to find out more about our perspective, study system, methods, and specific research projects…
Carolyn (Lindy) McBride

Associated Faculty, Ecology and Evolutionary Biology nd the Lewis-Sigler Institute for Integrative Genomics
Contact
csm7@princeton.edu 609-258-9598
Guyot Hall, M151
Research Area
Genetics & GenomicsResearch Focus
Genes and Neural Circuits Underlying Behavioral EvolutionGenes and Neural Circuits Underlying Behavioral Evolution
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GCaMP Imaging in Mosquitoes: Central Nervous System. Cold Spring Harb Protoc. 2023 ;2023(3):pdb.top107682. .
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Two-Photon Calcium Imaging in the Brain of Mosquitoes. Cold Spring Harb Protoc. 2023 ;2023(3):pdb.prot108070. .
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Enhanced mosquito vectorial capacity underlies the Cape Verde Zika epidemic. PLoS Biol. 2022 ;20(10):e3001864. .
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No association between habitat, autogeny and genetics in Moroccan Culex pipiens populations. Parasit Vectors. 2022 ;15(1):405. .
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Mosquito brains encode unique features of human odour to drive host seeking. Nature. 2022 ;605(7911):706-712. .
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Larval sites of the mosquito in forest and domestic habitats in Africa and the potential association with oviposition evolution. Ecol Evol. 2021 ;11(22):16327-16343. .
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Development of a pan-neuronal genetic driver in mosquitoes. Cell Rep Methods. 2021 ;1(3). .
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Climate and Urbanization Drive Mosquito Preference for Humans. Curr Biol. 2020 ;30(18):3570-3579.e6. .
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Enhanced Zika virus susceptibility of globally invasive populations. Science. 2020 ;370(6519):991-996. .
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Evolution of olfactory circuits in insects. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2020 ;206(3):353-367. .
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How a fly came to love the vomit fruit. Nature. 2020 ;579(7799):345-346. .
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Correction to: Evolution of olfactory circuits in insects. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2020 ;206(4):663. .
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Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes. Neuron. 2020 ;108(6):1163-1180.e12. .
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Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature. 2018 ;563(7732):501-507. .
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Malaria Parasites Alter Human Odor to Attract Mosquito Vectors. Trends Parasitol. 2018 ;34(7):547-549. .
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Genes and Odors Underlying the Recent Evolution of Mosquito Preference for Humans. Curr Biol. 2016 ;26(1):R41-6. .
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The neurotranscriptome of the Aedes aegypti mosquito. BMC Genomics. 2016 ;17:32. .
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Evolution of mosquito preference for humans linked to an odorant receptor. Nature. 2014 ;515(7526):222-7. .
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orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET. Nature. 2013 ;498(7455):487-91. .
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Worldwide patterns of genetic differentiation imply multiple 'domestications' of Aedes aegypti, a major vector of human diseases. Proc Biol Sci. 2011 ;278(1717):2446-54. .
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Field studies reveal strong postmating isolation between ecologically divergent butterfly populations. PLoS Biol. 2010 ;8(10):e1000529. .