Michel Nofal, Tim Wang, Lifeng Yang, Connor S.R. Jankowski, Sophia Hsin-Jung Li, Seunghun Han, Lance Parsons, Alexander N. Frese, Zemer Gitai, Tracy G. Anthony, Martin Wühr, David M. Sabatini, Joshua D. Rabinowitz, GCN2 adapts protein synthesis to scavenging-dependent growth, Cell Systems, 2021,
The Gitai, Rabinowitz, and Wuhr labs have collaborated with a number of labs in the area to publish two independent research articles on mammalian metabolism, both available online and to be printed in Cell Systems. Together with Tracey Anthony at Rutgers the Gitai, Rabinowitz and Wuhr labs have identified a key role for the protein kinase GCN2 in adapting pancreatic cancer cells to scavenging-dependent growth by preventing ribosome stalling without slowing protein synthesis. A second article, in collaboration with Joseph Baur at the University of Pennsylvania and Xiaoyang Su at Rutgers, reveals how the chronological aging affects the metabolic flux of the essential coenzyme NAD+, whose concentrations have been shown to decline with age across the body, and shows that NAD+ biosynthetic flux is maintained in aged mice.