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Andres Blanco, U Penn
Reversible & irreversible cell fate decisions: the role of chromatin in regulating blood cancel cell identify Viral Pathogens​
Apr 17, 2024, 12:00 pm

Acute myeloid leukemia (AML) is a poor-prognosis hematological malignancy characterized by differentiation blockade and uncontrolled proliferation. Epigenetic programs influence AML cell fate decisions, and their mis-regulation can promote differentiation arrest. It is therefore of paramount importance to identify the regulators of…

Location
Thomas Laboratory-003
Butler Seminar Series
Dorothy Lerit, Emory University
The conserved RNA-binding protein CPEB/Orb2 safeguards against microcephaly
Apr 24, 2024, 12:00 pm

Microcephaly is a congenital birth defect manifesting in small head and brain size and associated with intellectual disabilities and developmental delay. While the leading cause of heritable microcephaly is centrosome deregulation, numerous other genes, including RNA-binding proteins, are also implicated. We identified cytoplasmic…

Location
Thomas Laboratory-003
Butler Seminar Series
Mansi Srivastava, Harvard University
Mechanisms of regeneration and their evolution
May 1, 2024, 12:00 pm

Wound repair and regeneration are fundamental features of animal biology, yet little is known about how these pathways compare across animal lineages. The goals of my research program are: 1) to identify cellular and genetic mechanisms for whole-body regeneration, and 2) to create a framework for rigorous cross-species comparisons to understand…

Location
Thomas Laboratory-003
Butler Seminar Series
Arielle Woznica, UT Austin
Choanoflagellates and the origin of animal immunity
May 8, 2024, 12:00 pm

All animals rely on innate immune responses to protect them from invading pathogens. But how did immunity in animals first evolve? By studying the closest living relatives of animals, the choanoflagellates, we can gain insight into the evolution of animal immune pathways, while uncovering new mechanisms of immunity.

Location
Thomas Laboratory-003
Butler Seminar Series
Andrew Goodman, Yale University SOM
Microbiome Dynamics During Infection
May 15, 2024, 12:00 pm

The gut microbiome is an “internal ecosystem” with widespread impacts on health, disease, and response to treatment. I will overview our recent studies that explore the interplay between microbiome, host, and pathogens and how medical drugs can reshape these interactions.

Location
Thomas Laboratory-003
Butler Seminar Series
Wenhan Zhu, Vanderbilt University
May 22, 2024, 12:00 pm
Location
Thomas Laboratory-003
Butler Seminar Series