Samantha Morris, PhD. (Washington University in St. Louis)

New genomic technologies to deconstruct cell identity in development and reprogramming
Mar 16, 2022, 12:00 pm1:00 pm
Thomas Laboratory, 003 or via Zoom
Hybrid Seminar - open to those participating in the Princeton Asymptomatic Testing Program


Samantha Morris
Associate Professor of Genetics and Developmental Biology
Washington University


Event Description

A mechanistic understanding of how cell identity is established and maintained is fundamental to the precise engineering of cell fate. Here, I will present new genomic technologies developed by my lab to permit single-cell lineage tracing throughout reprogramming, accompanied by recording of TF-binding and chromatin accessibility profiling. Integrating this information using our unique computational tools for interrogating gene regulatory networks delivers a systems-level understanding of how cell identity can be manipulated via lineage reprogramming. We also apply these methods to understand how cell identity is naturally programmed during differentiation and development. The deconstruction of cell identity via these approaches supports precision engineering of cell fate.


Hosted by Jared Toettcher, Molecular Biology Dept.
Event Category
Butler Seminar Series