Sai Li, PhD (Tsinghua University) - In Person Only (restricted to the PU community))

in situ architecture and neutralization mechanism of SARS-CoV-2
Nov 8, 2021, 9:30 am10:30 am
Schultz Laboratory, 107
Restricted to faculty, staff and students at Princeton University


Sai Li
Associate Professor
School of Life Sciences, Tsinghua University


Event Description

Using cryo-electron tomography, we have visualized the intact SARS-CoV-2 and its key variants at subnanometer resolution, discovering many unique features on the native structures and assembly of the virus. Novel neutralization mechanisms have also been unveiled in situ by imaging the virus-antibody complexes. These findings contributed to the understanding of the nature of the virus, and have provided implications for the vaccine and therapeutic design against COVID-19.


Nieng Yan, Molecular Biology Dept.
Event Category
Special Seminar