Ramnik Xavier (Harvard Medical School)

Ramnik Xavier (Harvard Medical School)

Butler Seminar Series

Event Date/Location

November 29, 2017 - 12:00 pm
Thomas Laboratory 003

Speaker

  • Picture of Dr. Xavier

    Ramnik Xavier

    Professor
    Harvard Medical School

    Dr. Ramnik Xavier is Chief of Gastroenterology at Massachusetts General Hospital (MGH), Kurt Isselbacher Professor of Medicine at Harvard Medical School, and an Institute Member at the Broad Institute of Harvard and MIT.

    In addition to his roles as director of the Center for the Study of Inflammatory Bowel Disease at MGH and co-director of Center for Microbiome Informatics and Therapeutics at MIT, he is also a founding member of the Center for Computational and Integrative Biology.

Topic

Microbes, Metabolism and Autoimmunity

Abstract: Taxonomic and functional changes to the composition of the gut microbiome have been implicated in multiple human diseases. The presentation will focus on how the microbiota drives intestinal disease through alterations in microbial community architecture, disruption of the mucosal barrier, modulation of innate and adaptive immunity, and dysfunction of the enteric nervous system. Fecal microbiota transplantation (FMT) is a treatment for microbiome-associated diseases in which gut microbiota are transferred from a healthy donor to a patient. Clinical case studies will be used discuss  the forces governing bacterial engraftment in humans and design principles of bacterial therapeutics that target diseases ranging from ulcerative colitis to cancer

Audience

Free and open to the university community and the public.

Host

Mohamed Donia, Department of Molecular Biology