Qiang Guo (Max Planck Inst.)

Qiang Guo (Max Planck Inst.)

Special Seminar

Event Date/Location

January 30, 2019 -
12:00 pm to 1:00 pm
Schultz Laboratory 107

Speaker

  • Dr. Qiang Guo

    Max Planck Institute of Biochemistry

Topic

Cryo-EM/ET, a Tool to Dissect Structural Mechanisms of Neurodegenerative Diseases

The formation of protein aggregates is associated with multiple neurodegenerative disorders. For example, intracellular tau and extracellular Aβ, α-synuclein, and mutant Huntingtin aggregates respectively accumulate in the brain of patients with Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). All these proteins are sequence-unrelated but form similar highly ordered amyloid aggregates, however, the mechanisms how aggregation process affects cell function and viability remain enigmatic. Mutations, stress conditions and modifications predispose proteins to misfold and aggregate, which would have two faces: loss of critical physiological functions and gain of a toxic function. Here I will show the in situ structure of ALS related poly-GA aggregates and the in vitro structure of HD related Huntingtin to elucidate the mechanisms of toxicity behind the deposition of aggregates in both gain and loss of function aspect.

Audience

Free and open to the university community and the public.

Host

Nieng Yan, Department of Molecular Biology