Professor Kazuhiro AOKI, Ph.D (NIBB & NINS)

Visualization, quantification, and manipulation of ERK signaling with fluorescence live-cell imaging
Date
Nov 6, 2018, 9:30 am – 10:30 am
Thomas Laboratory, 118
Audience
Free and open to the university community and the public.

Speakers

Kazuhiro Aoki Ph.D
Professor
National Institute for Basic Biology
National Institutes of Natural Sciences
SOKENDAI (The Graduate University for Advanced Studies)

Details

The Ras-ERK MAPK signaling cascade has been highly conserved throughout evolution and plays a key role in many cellular processes, including proliferation, differentiation, survival, and tumorigenesis. Although the Ras-ERK signaling pathway has been extensively studied for decades, it is still unclear how the Ras-ERK signaling controls such diverse cellular processes. To address this issue, we have developed tools to visualize, quantify, and manipulate intracellular signaling with live cell imaging. Here, I will show two topics in our recent studies about (1) collective cell migration driven by the intercellular propagation of ERK activation, and (2) a genetically-encoded optogenetic tool for red/infrared light-mediated manipulation of cell signaling.
Sponsor
Jared Toettcher, Department of Molecular Biology
Event Category
Special Seminar