Professor Kazuhiro AOKI, Ph.D (NIBB & NINS)

Professor Kazuhiro AOKI, Ph.D (NIBB & NINS)

Special Seminar

Event Date/Location

November 6, 2018 -
9:30 am to 10:30 am
Thomas Laboratory 118

Speaker

  • Picture of Professor Kazuhiro Aoki

    Kazuhiro Aoki Ph.D

    Professor
    National Institute for Basic Biology
    National Institutes of Natural Sciences
    SOKENDAI (The Graduate University for Advanced Studies)

Topic

Visualization, quantification, and manipulation of ERK signaling with fluorescence live-cell imaging

The Ras-ERK MAPK signaling cascade has been highly conserved throughout evolution and plays a key role in many cellular processes, including proliferation, differentiation, survival, and tumorigenesis. Although the Ras-ERK signaling pathway has been extensively studied for decades, it is still unclear how the Ras-ERK signaling controls such diverse cellular processes. To address this issue, we have developed tools to visualize, quantify, and manipulate intracellular signaling with live cell imaging. Here, I will show two topics in our recent studies about (1) collective cell migration driven by the intercellular propagation of ERK activation, and (2) a genetically-encoded optogenetic tool for red/infrared light-mediated manipulation of cell signaling.

Audience

Free and open to the university community and the public.

Host

Jared Toettcher, Department of Molecular Biology