Date Nov 6, 2018, 9:30 am – 10:30 am Location Thomas Laboratory, 118 Audience Free and open to the university community and the public. Speakers Kazuhiro Aoki Ph.D Professor National Institute for Basic Biology National Institutes of Natural Sciences SOKENDAI (The Graduate University for Advanced Studies) Details Event Description The Ras-ERK MAPK signaling cascade has been highly conserved throughout evolution and plays a key role in many cellular processes, including proliferation, differentiation, survival, and tumorigenesis. Although the Ras-ERK signaling pathway has been extensively studied for decades, it is still unclear how the Ras-ERK signaling controls such diverse cellular processes. To address this issue, we have developed tools to visualize, quantify, and manipulate intracellular signaling with live cell imaging. Here, I will show two topics in our recent studies about (1) collective cell migration driven by the intercellular propagation of ERK activation, and (2) a genetically-encoded optogenetic tool for red/infrared light-mediated manipulation of cell signaling. Sponsor Jared Toettcher, Department of Molecular Biology Event Category Special Seminar
