Peijun Zhang (Univ of Oxford)
October 30, 2019 -
12:00 pm to 1:00 pm
Thomas Laboratory 003
Professor Peijun Zhang obtained her Ph.D. in Biophysics and Physiology from University Virginia, M.S. in Physics and B.S. in Electrical Engineering from Nanjing University, China. She was a postdoc and subsequently a staff scientist at the National Cancer Institute, NIH. In 2006, she joined the faculty of the University of Pittsburgh, and was promoted to associate professor with tenure in 2012. In 2016, she joined the University of Oxford as a full professor, and jointly as the founding director of eBIC (the UK National Electron Bio-imaging Centre) at the Diamond Light Source. Her research focuses on the molecular mechanisms of large protein complexes and assemblies, in particular those involved in HIV-1 pathogenesis and bacterial chemotaxis signaling, by developing and combining novel technologies for high-resolution cryoEM and cryoET. She received many awards, including “Carnegie Science Emerging Female Scientist Award” (2014) and “Wellcome Trust Investigator Award” (2017).
Interrogating HIV-1 On A New Level
Cryo-electron microscopy is playing a key role in the understanding HIV-1 infection and development of new drugs and therapeutic strategies for HIV-1 prevention and treatment. Over the past decade we have made a significant progress in determining structural mechanisms of HIV-1 capsid assembly, disassembly, maturation, and interactions with many host factors, through developing cutting-edge cryoEM technologies that bring unprecedented resolution and enable in situ structures of large assemblies and complexes in their native cellular environment. We use an integrative approach combining structural methods with retrovirology, cell biology and computer simulations, to better understand the infection process. Future cryoEM development, in particular on the correlative in situ microscopy, will allow us generate a framework for the development of new therapeutic interventions of HIV-1 and other pathogenic viruses.
Free and open to the university community and the public.
Nieng Yan, Department of Molecular Biology