Nicolas Plachta, PhD (Perelman) - Webinar (In Person restricted to the PU community)

Imaging how cells choose their fate, shape and position in the early mammalian embryo
Nov 10, 2021, 12:00 pm1:00 pm
Thomas Laboratory, LTL003
Restricted to faculty, staff and students at Princeton University


Nicolas Plachta
William Richard Gordon President’s Professor in Genetics
Perelman School of Medicine, University of Pennsylvania


Event Description

Our lab has pioneered the use of live-imaging approaches to study how the preimplantation embryo forms. Our findings have revealed heterogeneities in transcription factor dynamics in the early mouse embryo, which predict the specification of the first differentiated cell lineages (the ICM and trophectoderm). We have also discovered many new forms of cytoskeletal organization that regulate the establishment of cell polarity and tissue organization in the embryo, a new type of mitotic spindle that drives the first asymmetric cell divisions, and nuclear mechanosensing processes that enable cells to integrate mechanical forces with fate decisions in vivo.


Co-hosted by Danelle Devenport & Eszter Posfai, Molecular Biology Dept.
Event Category
Butler Seminar Series