Lawrence Shapiro (Columbia University)

Lawrence Shapiro (Columbia University)

Butler Seminar Series

Event Date/Location

February 21, 2018 -
12:00 pm to 1:00 pm
Thomas Laboratory 003


  • Lawrence S Shapiro

    Associate Professor
    Columbia University, College of Physicians & Surgeons
    Dept. of Biochemistry and Molecular Biophysics

    Lawrence Shapiro is Professor of Biochemistry and Molecular Biophysics at Columbia University. His work is focused on the structure and function of molecules that function in cell adhesion, tissue patterning, and adaptive immunity.


Clustered protocadherins and neuronal self-recognition in vertebrates

Self-avoidance is a critical feature of all nervous systems, for example preventing the formation of self-synapses (autapses), while allowing their formation with non-self neurons Clustered protocadherins (Pcdhs) mediate neuronal self-avoidance  in vertebrates by enabling neurons to distinguish self from non-self.. To accomplish this function, Pcdhs are expressed stochastically in neurons to provide single-cell identities. Their structures and interactions suggest a mechanism by which only ~60 Pcdh isoforms can assign near-unique identities to each vertebrate neuron.


Free and open to the university community and the public.


Danelle Devenport, Department of Molecular Biology