Julie Segre (National Human Genome Research Institute of NIH) Webinar

Julie Segre (National Human Genome Research Institute of NIH) Webinar

Butler Seminar Series

Event Date/Location

November 18, 2020 - 12:00 pm to 1:00 pm
Thomas Laboratory

Speaker

  • Julie Segre

    Chief and Senior Investigator of the Translational and Functional Genomics Branch in the National Human Genome Research Institute at the National Institutes of Health.
    National Institutes of Health
    NIH Intramural Sequencing Center
    NIH Roadmap Human Microbiome Project
    Elected to the National Academy of Medicine in 2019
    Elected to the American Academy of Arts and Sciences in 2020

    Dr. Julie Segre received her B.A. summa cum laude in mathematics from Amherst College, where she now serves on the board of trustees. She received her Ph.D. in 1996 from the Massachusetts Institute of Technology in the laboratory of Eric Lander, Ph.D., and the newly formed genome center. Dr. Segre then performed postdoctoral training with Elaine Fuchs, Ph.D., an expert in skin biology, at the University of Chicago.

    Dr. Segre joined the National Human Genome Research Institute of NIH in 2000 and was promoted to a senior investigator with tenure in 2007. Dr. Segre's laboratory utilizes high-throughput sequencing and develops algorithms to study the microbial diversity of human skin in both health and disease states, with a focus on eczema and other microbial-associated infections. Dr. Segre published the first topographical maps of human skin bacterial and fungal diversity. Dr. Segre's laboratory also develops genomic tools to track hospital-acquired infections of multi-drug resistant organisms, including the NIH's recent Klebsiella pneumoniae outbreak.

    Dr. Segre's research is based on active collaborations with the NIH Intramural Sequencing Center and the clinical departments of Infection Control, Microbiology, and Dermatology. Dr. Segre is a leader in the NIH Roadmap Human Microbiome Project, communicating with multiple media sources to promote the concept of humans as ecological landscapes. Together with the NIH epidemiologist, Tara Palmore, M.D., Segre received the 2013 Service to America Medal, considered among the most prestigious for a federal employee, for their work to establish the clinical utility of microbial genomics.

Topic

Human skin microbiome: Friend and Foe

The varied topography of human skin offers a unique opportunity to study how the body’s microenvironments influence the functional and taxonomic composition of microbial communities. However, the paucity of commensal microbial genomes has limited our ability to comprehensively interpret the structure and function of these communities. We combined extensive culturing and co-assembly of shotgun metagenomic datasets spanning multiple body sites of multiple individuals to elucidate novel constituents, structure and functions of the human skin microbiome.

 

Candida auris is an emerging multi-drug resistant fungal pathogen. C. auris skin colonization results in environmental shedding, which underlies hospital transmissions, and predisposes patients to subsequent infections. Combining culturing and skin microbiome sequencing of an outbreak at a high-acuity long term care facility provided novel insight into prevalence and site tropism for C. auris colonization.  We developed a murine skin topical exposure model for C. auris to dissect risk factors predisposing patients for colonization and to test interventions that might protect patients.

Audience

Free and open to the university community and the public.

Host

Ned Wingreen & Mohamed Donia, Department of Molecular Biology