The dendritic cell (DC) system is intricate and comprised of many subsets. Much effort had been devoted to characterizing human DC subsets and their functions. However, until recently, most studies used low-dimensional approaches that only allow for the analysis of a discrete number of parameters at a single cell level. To overcome this shortcoming, we adopted a suite of high-dimensional single-cell technologies that enable in-depth studies of individual DCs in human and mouse models. Using these approaches, we have uncovered the DC network at a level of detail and resolution never achieved before. During my talk, I will share some of these exciting discoveries and their implications for the outcome of immune responses.