Judi Allen (Univ of Manchester, UK)

Judi Allen (Univ of Manchester, UK)

Special Seminar

Event Date/Location

November 14, 2019 - 12:30 pm
Guyot Hall 10

Speaker

  • Professor Judi Allen

    Judi Allen

    Professor
    University of Manchester, UK

    Judi Allen has a B.Sc. from Bates College, Maine and obtained her PhD from the University of California, Berkeley in 1991, following several years in the Biotech industry. She went to Imperial College, London for her postdoc and subsequently moved to Edinburgh, where she established her own group with an MRC Senior Fellowship in 1997.  In 2005, Judi became Professor of Immunobiology and in 2016 joined the Faculty of Life Sciences at the University of Manchester.  Judi is a Fellow of the Royal Society of Edinburgh, a Fellow of the Royal Society of Biology, and a Fellow of the Academy of Medical Sciences.

Topic

Learning from Helminths: Macrophages, Type 2 Immunity & Tissue Repair

Infection with parasitic worms (helminths) is strongly associated with the induction of a type 2 immune response, which is beneficial for the host by controlling parasite numbers, reducing inflammation and repairing damage caused by tissue migrating parasites. Macrophages with a distinct type 2 expression profile and are found in high numbers at the site of helminth infection, but also in non-infectious settings such as tissue injury. The infectious agent, the host genotype and the local site of infection/injury, together dictate the macrophage phenotype and whether the increase in macrophage numbers is due predominantly to proliferation of resident cells or recruitment of monocytes from the blood. A major product of macrophages at the site of helminth infection is the chitinase-like protein YM1. The Allen Lab recently discovered an unexpected relationship between YM1 and IL-17, a highly inflammatory cytokine, associated with many autoimmune diseases. Using helminth models, the lab aims to understand the complex relationship between IL-17 and type 2 immunity and unravel how type 2 immune responses regulate tissue repair.

Audience

Free and open to the university community and the public.

Host

Andrea Graham & Alex Ploss, Departments of Ecology and Evolutionary Biology & Molecular Biology