Judi Allen (Univ of Manchester, UK)

Learning from Helminths: Macrophages, Type 2 Immunity & Tissue Repair
Nov 14, 2019, 12:30 pm12:30 pm
Guyot Hall, 10
Free and open to the university community and the public.


Judi Allen
University of Manchester, UK


Event Description

Infection with parasitic worms (helminths) is strongly associated with the induction of a type 2 immune response, which is beneficial for the host by controlling parasite numbers, reducing inflammation and repairing damage caused by tissue migrating parasites. Macrophages with a distinct type 2 expression profile and are found in high numbers at the site of helminth infection, but also in non-infectious settings such as tissue injury. The infectious agent, the host genotype and the local site of infection/injury, together dictate the macrophage phenotype and whether the increase in macrophage numbers is due predominantly to proliferation of resident cells or recruitment of monocytes from the blood. A major product of macrophages at the site of helminth infection is the chitinase-like protein YM1. The Allen Lab recently discovered an unexpected relationship between YM1 and IL-17, a highly inflammatory cytokine, associated with many autoimmune diseases. Using helminth models, the lab aims to understand the complex relationship between IL-17 and type 2 immunity and unravel how type 2 immune responses regulate tissue repair.

Andrea Graham & Alex Ploss, Departments of Ecology and Evolutionary Biology & Molecular Biology
Event Category
Special Seminar