Jennifer Lippencott-Schwartz (Janelia HHMI)
May 1, 2019 -
12:00 pm to 1:00 pm
Thomas Laboratory 003
Jennifer Lippincott-Schwartz is a senior group leader at Janelia Research Campus. Her research uses live cell imaging approaches to analyze the spatio-temporal behavior and dynamic interactions of molecules in cells. Lippincott-Schwartz earned a master’s degree in Philip Hanawalt’s lab at Stanford University and a PhD in Douglas Fambrough’s lab at Johns Hopkins University. She did postdoctoral work with Richard Klausner at the National Institutes of Health, where she later became a primary investigator and Chief of the Section on Organelle Biology in the Cell Biology and Metabolism Branch. In 2016, Lippincott-Schwartz moved her lab to Janelia, where she continues to investigate cell biology, but in the context of the brain.
Eukaryotic organelles: deciphering their interdependency, structure and dynamics with new imaging technologies
Powerful new ways to image the internal structures and complex dynamics of cells are revolutionizing cell biology and bio-medical research. In this talk, I will focus on how emerging fluorescent technologies are increasing spatio-temporal resolution dramatically, permitting simultaneous multispectral imaging of multiple cellular components. In addition, results will be discussed from whole cell milling using Focused Ion Beam Electron Microscopy (FIB-SEM), which reconstructs the entire cell volume at 4 voxel resolution. Using these tools, it is now possible to begin constructing an “organelle interactome”, describing the interrelationships of different cellular organelles as they carry out critical functions. The same tools are also revealing new properties of organelles and their trafficking pathways, and how disruptions of their normal functions due to genetic mutations may contribute to important diseases
Free and open to the university community and the public.
Kate Cook, Graduate Student, Department of Molecular Biology