Date Oct 26, 2016, 12:00 pm – 12:00 pm Location Thomas Laboratory, 003 Audience Free and open to the university community and the public. Speakers Jean-Paul Vincent Francis Crick Institute Details Event Description During development, tissue growth and pattern formation must be coordinated to ensure that the appropriate number of cells is allocated to various substructures. Indeed, the signalling molecules that specify positional information often also control growth. As a model system to study the control of patterning in growth in developing tissues, we use the wing precursors of Drosophila. In this tissue, the two main secreted signals that organise patterning, Wingless (the main Wnt of Drosophila) and Dpp (a TGF-beta) are required for growth. Their dual roles in patterning and growth requires a tight regulation of their distribution and activity. I will first discuss how the range of Wg and Dpp is established and modulated. I will then outline our attempts to control the spatial organisation, timing, and intensity of these signals in order to assess how signalling activity contribute to tissue growth. Sponsor Paul Schedl, Department of Molecular Biology Event Category Butler Seminar Series