Jean-Paul Vincent (Francis Crick Institute)

Signals that control growth and patterning in developing epithelia
Oct 26, 2016, 12:00 pm12:00 pm
Thomas Laboratory, 003
Free and open to the university community and the public.


Jean-Paul Vincent
Francis Crick Institute


Event Description

During development, tissue growth and pattern formation must be coordinated to ensure that the appropriate number of cells is allocated to various substructures. Indeed, the signalling molecules that specify positional information often also control growth. As a model system to study the control of patterning in growth in developing tissues, we use the wing precursors of Drosophila. In this tissue, the two main secreted signals that organise patterning, Wingless (the main Wnt of Drosophila) and Dpp (a TGF-beta) are required for growth. Their dual roles in patterning and growth requires a tight regulation of their distribution and activity.  I will first discuss how the range of Wg and Dpp is established and modulated. I will then outline our attempts to control the spatial organisation, timing, and intensity of these signals in order to assess how signalling activity contribute to tissue growth.

Paul Schedl, Department of Molecular Biology
Event Category
Butler Seminar Series