Geraldine Seydoux (Johns Hopkins University)

Geraldine Seydoux (Johns Hopkins University)

Special Seminar

Event Date/Location

January 22, 2018 - 4:00 pm
Thomas Laboratory 003

Speaker

  • Picture of Dr. Seydoux

    Geraldine Seydoux

    Professor, HHMI Investigator
    Johns Hopkins University
    School of Medicine

    Dr. Geraldine Seydoux is the Huntington Sheldon Professor in Medical Discovery in the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine and an investigator with the Howard Hughes Medical Institute. Her work examines how early embryos develop into complex asymmetric structures comprising many cell types.

    Seydoux is best known for finding that global inhibition of mRNA synthesis is an essential first step in the establishment of the germline. Currently, her lab is studying a family of intrinsically-disordered proteins that scaffold RNA granules. The Seydoux lab is also developing new methods for genome editing using CRISPR technology.  

    Dr. Seydoux received her B.S. in biochemistry from the University of Maine at Orono in 1986, and completed her Ph.D. in molecular biology at Princeton University in 1991. After a postdoctoral fellowship in developmental biology at the Carnegie Institute of Washington, she joined the faculty of Johns Hopkins in 1995 as an assistant professor. She became an associate professor in 2000, and accepted the mantle of full professor in 2005.

    Dr. Seydoux has authored numerous peer-reviewed publications and her work has garnered several awards, including a MacArthur Fellowship in 2001. She was elected to the American Academy of Arts and Sciences in 2013 and to the National Academy of Sciences in 2016. She assumed the role of vice dean for Basic Research at the Johns Hopkins School of Medicine in 2017.

Topic

Kuggee Vallee Lecture - Are RNA granules liquid organelles? Regulation of RNA granule assembly by intrinsically-disordered proteins

RNA granules are RNA-rich organelles that form without enveloping membranes. RNA granules have been proposed to form by liquid-liquid phase separation, an equilibrium process similar to the formation of oil droplets in water. We have identified the proteins that scaffold the P granules of C. elegans and developed methods to examine RNA granules ex vivo. We will present evidence that RNA granules are build around dense cores that require continuous ATP hydrolysis to prevent solidification.

Audience

Free and open to the university community and the public.

Host

Bonnie Bassler, Department of Molecular Biology