Proteins carry out most of the work in living cells.  They catalyze chemical reactions, mediate the movement of molecules across biological membranes, and help maintain cell shape.  I will discuss how the bacterium Salmonella enterica promotes general and specific changes in its proteome when experiencing different growth and environmental conditions.  I will focus on the mechanisms that govern protease specificity, which enable cells to selectively degrade, or spare degradation, specific protease substrates.  I will talk about the physiological consequences that these mechanisms have for different organisms.

References

1.   Gao, X, Yeom J and Groisman, EA. (2019). The expanded specificity and physiological role of a widespread N-degron recognin. Proc Natl Acad Sci USA 116, 18629-18637. PMID: 31451664, PMC6744884

2.   Yeom J and Groisman, EA. (2019). Activator of one protease transforms into inhibitor of another in response to nutritional signals. Genes Dev 33, 1280-1292. PMID: 31371438, PMC6719616

3.   Yeom, J, Pontes, MH , Choi, J and Groisman EA. (2018). A protein that controls the onset of a Salmonella virulence program. EMBO J 37pii: e96977. PMID: 29858228

4.   Yeom J, Gao, X and Groisman, EA. (2018). Reduction in adaptor amounts establishes hierarchy among protease substrates. Proc Natl Acad Sci USA 115, E4483-E4492. PMID: 29686082,   PMC5948988