Eduardo Groisman (Yale)

The Control of Protein Homeostasis
Dec 4, 2019, 12:00 pm1:00 pm
Thomas Laboratory, 003
Free and open to the university community and the public.


Eduardo Groisman
Waldemar Von Zedtwitz Professor of Microbial Pathogenesis
Yale University


Event Description

Proteins carry out most of the work in living cells.  They catalyze chemical reactions, mediate the movement of molecules across biological membranes, and help maintain cell shape.  I will discuss how the bacterium Salmonella enterica promotes general and specific changes in its proteome when experiencing different growth and environmental conditions.  I will focus on the mechanisms that govern protease specificity, which enable cells to selectively degrade, or spare degradation, specific protease substrates.  I will talk about the physiological consequences that these mechanisms have for different organisms.


1.   Gao, X, Yeom J and Groisman, EA. (2019). The expanded specificity and physiological role of a widespread N-degron recognin. Proc Natl Acad Sci USA 116, 18629-18637. PMID: 31451664, PMC6744884

2.   Yeom J and Groisman, EA. (2019). Activator of one protease transforms into inhibitor of another in response to nutritional signals. Genes Dev 33, 1280-1292. PMID: 31371438, PMC6719616

3.   Yeom, J, Pontes, MH , Choi, J and Groisman EA. (2018). A protein that controls the onset of a Salmonella virulence program. EMBO J 37pii: e96977. PMID: 29858228

4.   Yeom J, Gao, X and Groisman, EA. (2018). Reduction in adaptor amounts establishes hierarchy among protease substrates. Proc Natl Acad Sci USA 115, E4483-E4492. PMID: 29686082,   PMC5948988

Tom Silhavy, Department of Molecular Biology
Event Category
Butler Seminar Series