Denis Duboule, PhD. (Universite de Geneve) - Webinar

Denis Duboule, PhD. (Universite de Geneve) - Webinar

Butler Seminar Series

Event Date/Location

April 28, 2021 - 12:00 pm to 1:00 pm
Thomas Laboratory


  • Denis Duboule University of Geneva

    Denis Duboule

    Professor of Developmental Genetics and Genomics
    University of Geneva
    Swiss National Research Center
    School of Life Sciences, École polytechnique fédérale de Lausanne

    Denis Duboule is a Swiss-French biologist. He earned his PhD in Biology in 1984 and is currently Professor of Developmental Genetics and Genomics at the École polytechnique fédérale de Lausanne and at the Department of Genetics and Evolution of the University of Geneva. Since 2001, he is the Director of the Swiss National Research Center "Frontiers in Genetics" and since 2017, he is also a professor at the Collège de France. He has notably worked on Hox genes, a group of genes involved in the formation of the body plan and of the limbs.


Hox genes regulation in mammalian embryos and pseudo-embryos

During vertebrate development, clustered Hox genes are activated in a precise time-sequence, leading to expression patterns necessary to properly establish the body plan. The mechanism underlying this in cis timing phenomenon (The Hox clock) has remained elusive ever since its initial observation in 1989, due to the difficulty to approach it using the small and complex early gastrulating mouse embryos. I will introduce this topic and discuss an alternative possibility, which is to use pseudo-embryos produced out of ES cells (referred to as gastruloids) to address this (largely overdue) question and will show some preliminary data indicating that this system may allow us to more efficiently tackle this issue in the next few years to come.


Free and open to the university community and the public.


Ricardo Mallarino and Eszter Posfai, Molecular Biology