David Rudner (Harvard Medical School)

How SMC condensin complexes compact and resolve replicated chromosomes: what Bacillus subtilis tells us
Dec 6, 2017, 12:00 pm12:00 pm
Thomas Laboratory, 003
Free and open to the university community and the public.


David Rudner
Harvard Medical School


Event Description

SMC condensin complexes play a central role in the compaction and resolution of replicated chromosomes in virtually all organisms. This highly conserved complex was discovered over two decades ago yet the mechanism by which it condenses chromosomes and promotes their resolution has remained enigmatic until very recently. Using chromosome conformation capture (Hi-C) we have characterized how the SMC complex functions in B. subtilis. Our findings provide a generalizable model for how these complexes compact and resolve replicated DNA in all organisms.

Ned Wingreen Department of Molecular Biology and Lewis-Sigler Institute for Integrative Genomics.
Event Category
Butler Seminar Series