David Pellman (Harvard Medical School)

Job’s dilemma for the genome: Why bad things happen to good chromosomes
Dec 13, 2017, 12:00 pm12:00 pm
Thomas Laboratory, 003
Free and open to the university community and the public.


David Pellman, M.D.
Professor of Pediatric Oncology& Cell Biology,
HHMI Investigator
Dana-Farber Cancer Institute, Harvard Medical School


Event Description
I will discuss our recent work to define mechanisms that generate rapid genome evolution, emphasizing work relevant to complex cancer genomes. I will focus on understanding mutational processes known as chromothripsis and chromosome breakage-fusion-bridge cycles. We are approaching these problems using reconstitution in Xenopus egg extracts and using a combination of live-cell imaging and single cell genomics that we call "Look-Seq".
Ginger Zakian, Department of Molecular Biology
Event Category
Butler Seminar Series