I will discuss our recent work to define mechanisms that generate rapid genome evolution, emphasizing work relevant to complex cancer genomes. I will focus on understanding mutational processes known as chromothripsis and chromosome breakage-fusion-bridge cycles. We are approaching these problems using reconstitution in Xenopus egg extracts and using a combination of live-cell imaging and single cell genomics that we call "Look-Seq".
Ginger Zakian, Department of Molecular Biology
Butler Seminar Series