Date Dec 13, 2017, 12:00 pm – 12:00 pm Location Thomas Laboratory, 003 Audience Free and open to the university community and the public. Speakers David Pellman, M.D. Professor of Pediatric Oncology& Cell Biology, HHMI Investigator Dana-Farber Cancer Institute, Harvard Medical School Details Event Description I will discuss our recent work to define mechanisms that generate rapid genome evolution, emphasizing work relevant to complex cancer genomes. I will focus on understanding mutational processes known as chromothripsis and chromosome breakage-fusion-bridge cycles. We are approaching these problems using reconstitution in Xenopus egg extracts and using a combination of live-cell imaging and single cell genomics that we call "Look-Seq". Sponsor Ginger Zakian, Department of Molecular Biology Event Category Butler Seminar Series