David Bartel (Whitehead Institute)

David Bartel (Whitehead Institute)

Butler Seminar Series

Event Date/Location

December 9, 2015 - 12:00 pm
Thomas Laboratory 003

Speaker

  • Photo of David Bartel

    David Bartel, Ph.D.

    Principal Investigator Whitehead Institute for Medical Research
    HHMI Investigator
    Professor of Biology, MIT
    Whitehead Institute for Medical Research

    David Bartel received his Ph.D. from Harvard in 1993 and has since headed a lab at the Whitehead Institute for Biomedical Research, where he is also an Investigator of the Howard Hughes Medical Institute and a Professor of Biology at MIT.  His lab initially studied the ability of RNA to catalyze reactions and more recently has focused on microRNAs and other regulatory RNAs.  Over the past 15 years his lab has contributed to the understanding of the genomics, biogenesis and regulatory targets of these RNAs, as well as the molecular and biological consequences of their actions in animals, plants and fungi.

Topic

MicroRNAs, poly(A) tails, and a developmental switch in the nature of translational control

We have been using molecular and computational approaches to find regulatory RNAs, identify the messages that they regulate, and then investigate molecular consequences of these regulatory interactions as well as their functions during development, oncogenesis, and other biological processes.  This talk will describe our current understanding of microRNAs, the mechanisms by which they repress gene expression, a switch in the nature of translational control that occurs in early metazoan development, and how this switch influences the ultimate consequences of miRNA-mediated repression.  

Audience

Free and open to the university community and the public

Host

Alexei Korennykh, Department of Molecular Biology