Dagmar Iber, PhD. (ETH Zurich) Webinar Only

Dagmar Iber, PhD. (ETH Zurich) Webinar Only

Butler Seminar Series

Event Date/Location

March 2, 2022 - 12:00 pm to 1:00 pm

Speaker

  • Dagmar Iber Photo

    Dagmar Iber

    Professor of Computational Biology
    ETH Zurich

    Dagmar Iber studied mathematics and biochemistry in Regensburg, Cambridge, and Oxford. She holds Master degrees and PhDs in both disciplines. After three years as a Junior Research Fellow in St John’s College, Oxford, Dagmar became a lecturer in Applied Mathematics at Imperial College London. Dagmar has joined ETH Zurich in 2008 after returning from an investment bank where she worked as an oil option trader for one year.

    Dagmar Iber’s group develops data-​based, predictive models to understand the spatio-​temporal dynamics of signaling networks. Close collaborations with experimental laboratories permit a cycle of model testing and improving. Her recent work focuses on mouse organogenesis (limb and brain development, lung and kidney branching morphogenesis) and simpler patterning systems to address more fundamental questions regarding the control of organ growth and the robustness of signalling mechanisms to evolutionary change.

Topic

Precision and Robustness of Epithelial Morphogenesis

Developmental outcomes are remarkably constant despite environmental, inter-individual, and evolutionary changes. My group focuses on the mechanisms that enable stereotypic lung and kidney branching morphogenesis, and the precise development of the central nervous system. All three structures form via patterning, growth, and deformation of a single-layered pseudostratified epithelium. I will discuss the mechanisms that ensure precise epithelial patterning, the physical principles behind and the developmental consequences of the complex 3D cell shapes in pseudostratified epithelia, and finally the mechanical constraints that guide the deformation and outgrowth of the epithelium into its characteristic shape. 

 

Audience

Webinar Only

Host

Hosted by Celeste Nelson, Molecular Biology Dept.