My lab is interested in the functions of 3′UTRs. I will present our new insights into the regulation of mRNA localization to three cytoplasmic compartments and how localized protein synthesis modulates protein output by ten-fold.
We are also interested in the functions of cytoplasmic condensates in cells. So far, we have discovered TIS granules and the FXR1 network. Both cytoplasmic condensates promote protein complex assembly which requires cooperative action between motifs in mRNAs and motifs in proteins. I will present our unpublished data on FXR1.