Christine Mayr, MD PhD (Memorial Sloan Kettering Cancer Center) - Webinar

Christine Mayr, MD PhD (Memorial Sloan Kettering Cancer Center) - Webinar

Butler Seminar Series

Event Date/Location

October 27, 2021 - 12:00 pm to 1:00 pm
Thomas Laboratory LTL003

Speaker

  • Dr. Christine Mayr

    Christine Mayr

    Rachel Carson Professor of Ecology and Evolutionary Biology
    Yale

    Christine Mayr, M.D., Ph.D.

    Dr. Mayr received her M.D. from Free University in Berlin and her Ph.D. in Immunology from Humboldt University in Berlin, Germany. For her postdoc, she joined David Bartel’s lab at the Whitehead Institute. During her postdoc, she found that oncogenes can get activated through 3′UTR shortening. In 2009, she started her own laboratory in the Cancer Biology and Genetics Program of Memorial Sloan Kettering Cancer Center in New York. She is a full member of Sloan Kettering Institute and a Full Professor at the Gerstner Sloan Kettering Graduate School of Biomedical Science and at the Weill Cornell Medical College. Her lab studies the functions of mRNAs that go beyond their roles as templates for protein synthesis. Her lab discovered that 3′UTRs can regulate protein function by mediating protein-protein interactions. In 2016, she was awarded the NIH Director’s Pioneer Award to study this topic. More recently, her lab discovered two cytoplasmic condensates that promote protein complex assembly. The current focus of the lab is to annotate functions of long 3′UTRs and to learn how proteins take advantage of being translated in phase-separated cytoplasmic compartments.    

Topic

Protein complex assembly in cytoplasmic condensates

My lab is interested in the functions of 3′UTRs. I will present our new insights into the regulation of mRNA localization to three cytoplasmic compartments and how localized protein synthesis modulates protein output by ten-fold.   

We are also interested in the functions of cytoplasmic condensates in cells. So far, we have discovered TIS granules and the FXR1 network. Both cytoplasmic condensates promote protein complex assembly which requires cooperative action between motifs in mRNAs and motifs in proteins. I will present our unpublished data on FXR1.

 

Audience

Restricted to faculty, staff and students at Princeton University

Host

Liz Gavis, Molecular Biology Dept.