CANCELLED-Bianca Jones Marlin, Columbia Zuckerman Institute

CANCELLED-Bianca Jones Marlin, Columbia Zuckerman Institute

Butler Seminar Series

Event Date/Location

October 26, 2022 - 12:00 pm to 1:00 pm
Thomas Laboratory 003


  • Bianca Jones Marlin Photo

    CANCELLED-Bianca Jones Marlin

    Herbert and Florence Irving Assistant Professor of Cell Research at the Zuckerman Institute
    Columbia Zuckerman Institute

    Bianca Jones Marlin, Ph.D. is a neuroscientist and Herbert and Florence Irving Assistant Professor of Cell Research at the Zuckerman Institute at Columbia University in New York City. Her research investigates how organisms unlock innate behaviors at appropriate times, and how learned information is passed to subsequent generations via transgenerational epigenetic inheritance. Dr. Marlin combines neural imaging, behavior, and molecular genetics to uncover how learned behavior in the parent can become innate behavior in the offspring— work that promises to make a profound impact on societal brain health, mental well-being, and parenting.



Olfactory Fear Conditioning Biases Olfactory Stem Cell Receptor Fate

Stress can cause a host of adaptive and maladaptive biological responses that may be passed down from parent to offspring. The mouse olfactory epithelium (MOE) provides an ideal site to explore physiological responses to stress due to ongoing neurogenesis and unique receptor specificity. Previous studies have shown that olfactory cues paired with a stressful experience can influence neuronal composition in subsequent generations. These studies, albeit groundbreaking, were heavily contested in-part due to limitations in anatomical resolution and mechanistic insight. We use volumetric cellular resolution using iDISCO+ tissue clearing, light-sheet microscopy, and olfactory fear to investigate how aversive experiences alter receptor-specific cell number in the MOE across generations. By uncovering a mechanism by which the complex architecture of the MOE responds to odor fear conditioning, our study gives rise to the notion that learned adaptive change becomes innate.


Free and open to the university community and the public.


Coleen Murphy, Department of Molecular Biology