CANCELLED-Bianca Jones Marlin, Columbia Zuckerman Institute

Olfactory Fear Conditioning Biases Olfactory Stem Cell Receptor Fate
Oct 26, 2022, 12:00 pm1:00 pm
Thomas Laboratory, 003
Free and open to the university community and the public.


CANCELLED-Bianca Jones Marlin
Herbert and Florence Irving Assistant Professor of Cell Research at the Zuckerman Institute
Columbia Zuckerman Institute


Event Description

Stress can cause a host of adaptive and maladaptive biological responses that may be passed down from parent to offspring. The mouse olfactory epithelium (MOE) provides an ideal site to explore physiological responses to stress due to ongoing neurogenesis and unique receptor specificity. Previous studies have shown that olfactory cues paired with a stressful experience can influence neuronal composition in subsequent generations. These studies, albeit groundbreaking, were heavily contested in-part due to limitations in anatomical resolution and mechanistic insight. We use volumetric cellular resolution using iDISCO+ tissue clearing, light-sheet microscopy, and olfactory fear to investigate how aversive experiences alter receptor-specific cell number in the MOE across generations. By uncovering a mechanism by which the complex architecture of the MOE responds to odor fear conditioning, our study gives rise to the notion that learned adaptive change becomes innate.

Coleen Murphy, Department of Molecular Biology
Event Category
Butler Seminar Series