Ben Garcia (Univ of Penn)

Quantitative Proteomics for Understanding Cancer Epigenetics
May 22, 2019, 12:30 pm1:30 pm
Thomas Laboratory, 003
Free and open to the university community and the public.


Benjamin A. Garcia
Presidential Professor of Biochemistry and Biophysics
Univ of Penn
Perelman School of Medicine


Event Description

Histones are small proteins that package DNA into chromosomes, and a large number of studies have showed that several post-translational modification (PTM) sites on the histones are associated with both gene activation and silencing.  Along with DNA and small non-coding RNA, histone PTMs make up epigenetic mechanisms that control gene expression patterns outside of DNA sequence mutations. Dysregulation of these chromatin networks underlie several human diseases such as cancer. Here I will give an update on technology advancements that have allowed for high-throughput quantitative analyses of histone PTMs and chromatin structure, and how we are applying these methods to understand epigenetic reprogramming found in malignant peripheral nerve sheath tumors (MPNSTs). MPNST is an aggressive sarcoma with recurrent loss of function alterations in polycomb-repressive complex 2 (PRC2), a histone-modifying complex involved in transcriptional silencing

Martin Wuhr, Department of Molecular Biology
Event Category
Butler Seminar Series