Andrei N. Lupas, (Max Planck Institute)

Andrei N. Lupas, (Max Planck Institute)

Special Seminar

Event Date/Location

December 3, 2018 -
12:00 pm to 1:00 pm
Schultz Laboratory 107

Speaker

  • Picture of Andrei Lupas, Director of Department of Protein Evolution

    Andrei N. Lupas

    Director, Department of Protein Evolution
    Managing Director, Max Planck Institute for Developmental Biology
    Born on September 6th, 1963, in Bucharest/Romania. Study of biology TU Munich (1982-1985), Study of molecular biology Princeton Univ. (1985-1990), PhD (1991), Max Planck Institute for Biochemistry, Martinsried (1992-1997), SmithKline Beecham Pharmaceuticals, Collegeville (1997-2001), Director and Scientific Member at the Max Planck Institute for Developmental Biology (since 2001).

Topic

Axial helix rotation in transmembrane signal transduction

The mechanism(s) by which extracelullar stimuli are transmitted from the sensory domains of transmembrane receptors to the effector domains are still substantially under debate. Whereas the most widespread model for propagation of the stimulus is the piston model, in which the axial displacement of one receptor subunit relative to the other activates the effector domain, we have put forward the cogwheel model, in which axial rotation of the helices between two coiled-coil packing modes leads to the activation of the effector domain by a constrain-and-release mechanism. In this mechanism, the coiled-coil backbone of the receptor sequesters the catalytic effector domains in an inactive conformation, until axial rotation of its helices releases the effector domains to assume a catalytically productive conformation. We have recently shown that this model applies not only to histidine kinases, but also to adenylyl cyclases

Audience

Free and open to the university community and the public.

Host

Tom Silhavy, Department of Molecular Biology