Alex Schier (Harvard Univ.)

Alex Schier (Harvard Univ.)

Butler Seminar Series

Event Date/Location

November 7, 2018 -
12:00 pm to 1:00 pm
Thomas Laboratory 003

Speaker

Topic

Global views of development

The development of systems ranging from embryos to metastases is governed by regulatory factors that control specification trajectories and by cell division patterns that determine the lineage relationships of cells. I will illustrate how single-cell RNA sequencing and CRISPR-Cas9 genome editing provide new tools to reconstruct developmental trajectories and lineage trees at very large scales. I will discuss the opportunities and challenges for these technologies to provide new views of development (for more information see McKenna et al. Science 2016; Farrell et al. Science 2018; Raj et al. Nature Biotechnology 2018).

Audience

Free and open to the university community and the public.

Host

Becky Burdine & Ricardo Mallarino, Department of Molecular Biology