Innate and intrinsic host enzymes shaping RNA virus infection

Cellular enzymes such as kinases, phosphatases, and ubiquitin E3 ligases have been shown to have critical roles in regulating antiviral innate immunity. On the other hand, human enzymes are usurped by viral pathogens for their optimal replication in host cells. In this seminar, I will present our recent work on how host modifying enzymes modulate RNA virus infection either by regulating the antiviral type I interferon response or by directly modifying essential viral proteins.