Paulina Pawlica, Icahn SOM

Unmasking viral secrets: the many tricks of non-coding RNAs
Nov 20, 2023, 12:00 pm1:00 pm
Free and open to the university community and the public.


Paulina Pawlica
Assistant Professor, Microbiology
Assistant Professor, Genetics and Genomic Sciences
Icahn School of Medicine at Mount Sinai


Event Description

Viruses and their hosts are engaged in a constant struggle, much of which occurs at the not fully understood transcriptome level. Less than 5% of the human transcriptome consists of protein-coding messenger RNAs (mRNAs). Plentiful non-coding RNAs (ncRNAs) present in the cells modulate almost every process, including translation, splicing, and post-transcriptional mRNA regulation. Viruses produce their own ncRNAs, which often regulate host gene expression. However, the functions of most viral ncRNAs have remained elusive. We have recently discovered that SARS-CoV-2 produces a small microRNA-like ncRNA, which can downregulate host genes involved in the immune response. Our new results suggest the existence of additional unexpected roles for this ncRNA. 

AJ te Velthuis, Department of Molecular Biology
Event Category
Butler Seminar Series