Date Nov 8, 2023, 12:00 pm – 1:00 pm Location Guyot Hall 10 Audience Free and open to the university community and the public. Speakers Maksim Plikus Professor, Developmental & Cell Biology School of Biological Sciences UC Irvine Details Event Description Our cells can exist in a finite number of stable states. Yet, depending on tissue context, cell collectives work together toward a diverse array of morphologies and functions. In my talk I will use the model of mammalian skin to discuss two examples when distinct differentiated cell states are reused for novel tissue-level functions. First, I will discuss how the senescent state can endow one cell type with a novel signaling function, enabling it to potently activate resident stem cells for robust tissue growth. Next, I will discuss how the lipogenesis program can endow normally non-lipogenic cell lineage with novel morphological and biomechanical properties. These examples will demonstrate how reusing existing cellular programs presents a shortcut to achieving new tissue functions. Contacts Danelle Devenport, Department of Molecular Biology Stas Shvartsman, Department of Molecular Biology Event Category Butler Seminar Series