Maksim Plikus, UC Irvine

Reduce, Reuse, Recycle - How Skin Cells Repurpose Old Pathways for New Functions
Nov 8, 2023, 12:00 pm1:00 pm
Free and open to the university community and the public.


Maksim Plikus
Professor, Developmental & Cell Biology
School of Biological Sciences
UC Irvine


Event Description

Our cells can exist in a finite number of stable states. Yet, depending on tissue context, cell collectives work together toward a diverse array of morphologies and functions. In my talk I will use the model of mammalian skin to discuss two examples when distinct differentiated cell states are reused for novel tissue-level functions. First, I will discuss how the senescent state can endow one cell type with a novel signaling function, enabling it to potently activate resident stem cells for robust tissue growth. Next, I will discuss how the lipogenesis program can endow normally non-lipogenic cell lineage with novel morphological and biomechanical properties. These examples will demonstrate how reusing existing cellular programs presents a shortcut to achieving new tissue functions.

  • Danelle Devenport, Department of Molecular Biology
  • Stas Shvartsman, Department of Molecular Biology
Event Category
Butler Seminar Series