@article{4628,
  author = {Samantha Horwitz and Tamra Blue and Joseph Ambarian and Shotaro Hoshino and Mohammad Seyedsayamdost and Katherine Davis},
  title = {Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines.},
  abstract = { <p>Hydroxyalkylquinolines (HAQs) are ubiquitious natural products but their interactions with associated protein targets remain elusive. We report X-ray crystal structures of two HAQs in complex with dihydroorotate dehydrogenase (DHODH). Our results reveal the structural basis of DHODH inhibition by HAQs and open the door to downstream structure-activity relationship studies.</p> },
  year = {2022},
  journal = {RSC Chem Biol},
  volume = {3},
  pages = {420-425},
  month = {2022 Apr 06},
  issn = {2633-0679},
  doi = {10.1039/d1cb00255d},
  language = {eng},
}