@article{4587,
  keywords = {Computational Biology, Phosphorylation, Protein Processing, Post-Translational, Enzymes, Methylation, Biological Products, Peptides, Ribosomes, Protein Sorting Signals, Protein Engineering, Hydroxylation},
  author = {Manuel Montalb{\'a}n-L{\'o}pez and Thomas Scott and Sangeetha Ramesh and Imran Rahman and Auke van Heel and Jakob Viel and Vahe Bandarian and Elke Dittmann and Olga Genilloud and Yuki Goto and Mar{\'\i}a Burgos and Colin Hill and Seokhee Kim and Jesko Koehnke and John Latham and A James Link and Beatriz Mart{\'\i}nez and Satish Nair and Yvain Nicolet and Sylvie Rebuffat and Hans-Georg Sahl and Dipti Sareen and Eric Schmidt and Lutz Schmitt and Konstantin Severinov and Roderich S{\"u}ssmuth and Andrew Truman and Huan Wang and Jing-Ke Weng and Gilles van Wezel and Qi Zhang and Jin Zhong and J{\"o}rn Piel and Douglas Mitchell and Oscar Kuipers and Wilfred van der Donk},
  title = {New developments in RiPP discovery, enzymology and engineering.},
  abstract = { <p>Covering: up to June 2020Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 described the emerging commonalities in the biosynthesis of RiPPs and the opportunities they offered for bioengineering and genome mining. Since then, the field has seen tremendous advances in understanding of the mechanisms by which nature assembles these compounds, in engineering their biosynthetic machinery for a wide range of applications, and in the discovery of entirely new RiPP families using bioinformatic tools developed specifically for this compound class. The First International Conference on RiPPs was held in 2019, and the meeting participants assembled the current review describing new developments since 2013. The review discusses the new classes of RiPPs that have been discovered, the advances in our understanding of the installation of both primary and secondary post-translational modifications, and the mechanisms by which the enzymes recognize the leader peptides in their substrates. In addition, genome mining tools used for RiPP discovery are discussed as well as various strategies for RiPP engineering. An outlook section presents directions for future research.</p> },
  year = {2021},
  journal = {Nat Prod Rep},
  volume = {38},
  pages = {130-239},
  month = {2021 Jan 01},
  issn = {1460-4752},
  doi = {10.1039/d0np00027b},
  language = {eng},
}