@article{4495, keywords = {Animals, Mammals, CRISPR-Cas Systems, Gene Editing}, author = {Pengfei Zhang and Michelle Chan}, title = {A multifaceted signal recorder of cellular experiences using Cas12a base-editing.}, abstract = {

Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.

}, year = {2022}, journal = {Trends Biotechnol}, volume = {40}, pages = {1279-1281}, month = {2022 Nov}, issn = {1879-3096}, doi = {10.1016/j.tibtech.2022.07.009}, language = {eng}, }