@article{4222,
  keywords = {Animals, Multigene Family, Genomics, Female, Male, Genetic Variation, Genome, Insect, DNA Copy Number Variations, Genetics, Population, Molecular Sequence Annotation, Aedes, Dengue Virus, Reference Standards, Mosquito Vectors, Sex Determination Processes, Arbovirus Infections, Arboviruses, Glutathione Transferase, Insect Control, Insecticide Resistance, Pyrethrins},
  author = {Benjamin Matthews and Olga Dudchenko and Sarah Kingan and Sergey Koren and Igor Antoshechkin and Jacob Crawford and William Glassford and Margaret Herre and Seth Redmond and Noah Rose and Gareth Weedall and Yang Wu and Sanjit Batra and Carlos Brito-Sierra and Steven Buckingham and Corey Campbell and Saki Chan and Eric Cox and Benjamin Evans and Thanyalak Fansiri and Igor Filipovi{\'c} and Albin Fontaine and Andrea Gloria-Soria and Richard Hall and Vinita Joardar and Andrew Jones and Raissa Kay and Vamsi Kodali and Joyce Lee and Gareth Lycett and Sara Mitchell and Jill Muehling and Michael Murphy and Arina Omer and Frederick Partridge and Paul Peluso and Aviva Aiden and Vidya Ramasamy and Gordana Ra{\v s}i{\'c} and Sourav Roy and Karla Saavedra-Rodriguez and Shruti Sharan and Atashi Sharma and Melissa Smith and Joe Turner and Allison Weakley and Zhilei Zhao and Omar Akbari and William Black and Han Cao and Alistair Darby and Catherine Hill and J Spencer Johnston and Terence Murphy and Alexander Raikhel and David Sattelle and Igor Sharakhov and Bradley White and Li Zhao and Erez Aiden and Richard Mann and Louis Lambrechts and Jeffrey Powell and Maria Sharakhova and Zhijian Tu and Hugh Robertson and Carolyn McBride and Alex Hastie and Jonas Korlach and Daniel Neafsey and Adam Phillippy and Leslie Vosshall},
  title = {Improved reference genome of Aedes aegypti informs arbovirus vector control.},
  abstract = { <p>Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology~of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.</p> },
  year = {2018},
  journal = {Nature},
  volume = {563},
  pages = {501-507},
  month = {2018 Nov},
  issn = {1476-4687},
  doi = {10.1038/s41586-018-0692-z},
  language = {eng},
}