@article{4087,
  keywords = {Animals, Drosophila Proteins, Nuclear Proteins, Cell Communication, Female, Drosophila melanogaster, Cell Differentiation, Oocytes, Oogenesis, Germ Cells},
  author = {Caroline Doherty and Rocky Diegmiller and Manisha Kapasiawala and Elizabeth Gavis and Stanislav Shvartsman},
  title = {Coupled oscillators coordinate collective germline growth.},
  abstract = { <p>Developing oocytes need large supplies of macromolecules and organelles. A conserved strategy for accumulating these products is to pool resources of oocyte-associated germline nurse cells. In Drosophila, these cells grow more than 100-fold to boost their biosynthetic capacity. No previously known mechanism explains how nurse cells coordinate growth collectively. Here, we report a cell cycle-regulating mechanism that depends on bidirectional communication between the oocyte and nurse cells, revealing the oocyte as a critical regulator of germline cyst growth. Transcripts encoding the cyclin-dependent kinase inhibitor, Dacapo, are synthesized by the nurse cells and actively localized to the oocyte. Retrograde movement of the oocyte-synthesized Dacapo protein to the nurse cells generates a network of coupled oscillators that controls the cell cycle of the nurse cells to regulate cyst growth. We propose that bidirectional nurse cell-oocyte communication establishes a growth-sensing feedback mechanism that regulates the quantity of maternal resources loaded into the oocyte.</p> },
  year = {2021},
  journal = {Dev Cell},
  volume = {56},
  pages = {860-870.e8},
  month = {2021 Mar 22},
  issn = {1878-1551},
  doi = {10.1016/j.devcel.2021.02.015},
  language = {eng},
}