@article{4003,
  keywords = {Anti-Bacterial Agents, Humans, Microbiota, Hair Follicle, Skin, Propionibacterium acnes},
  author = {Jan Claesen and Jennifer Spagnolo and Stephany Ramos and Kenji Kurita and Allyson Byrd and Alexander Aksenov and Alexey Melnik and Weng Wong and Shuo Wang and Ryan Hernandez and Mohamed Donia and Pieter Dorrestein and Heidi Kong and Julia Segre and Roger Linington and Michael Fischbach and Katherine Lemon},
  title = {A  antibiotic modulates human skin microbiota composition in hair follicles.},
  abstract = { <p>The composition of the skin microbiota varies widely among individuals when sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin microbiota. Here, we used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster in  (formerly ), a human skin commensal bacterium that is widely distributed across individuals and skin sites. Experimental characterization of this biosynthetic gene cluster resulted in identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles revealed that cutimycin contributed to the ecology of the skin hair follicle microbiota and helped to reduce colonization of skin hair follicles by  species.</p> },
  year = {2020},
  journal = {Sci Transl Med},
  volume = {12},
  month = {2020 Nov 18},
  issn = {1946-6242},
  doi = {10.1126/scitranslmed.aay5445},
  language = {eng},
}