@article{3998,
  keywords = {Animals, Mice, Humans, Phenotype, Mice, Inbred C57BL, HEK293 Cells, Mice, Knockout, Aging, Mice, Transgenic, Membrane Glycoproteins, NAD, Inflammation, Liver, Cellular Senescence, Nicotinamide Mononucleotide, ADP-ribosyl Cyclase 1, Adipocytes, White, Adipose Tissue, White, Bone Marrow Transplantation},
  author = {Claudia Chini and Thais Peclat and Gina Warner and Sonu Kashyap and Jair Espindola-Netto and Guilherme de Oliveira and Lilian Gomez and Kelly Hogan and Mariana Tarrag{\'o} and Amrutesh Puranik and Guillermo Agorrody and Katie Thompson and Kevin Dang and Starlynn Clarke and Bennett Childs and Karina Kanamori and Micaela Witte and Paola Vidal and Anna Kirkland and Marco De Cecco and Karthikeyani Chellappa and Melanie McReynolds and Connor Jankowski and Tamara Tchkonia and James Kirkland and John Sedivy and Jan van Deursen and Darren Baker and Wim van Schooten and Joshua Rabinowitz and Joseph Baur and Eduardo Chini},
  title = {CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels.},
  abstract = { <p>Decreased NAD levels have been shown to contribute to metabolic dysfunction during aging. NAD decline can be partially prevented by knockout of the enzyme CD38. However, it is not known how CD38 is regulated during aging, and how its ecto-enzymatic activity impacts NAD homeostasis. Here we show that an increase in CD38 in white adipose tissue (WAT) and the liver during aging is mediated by accumulation of CD38 immune cells. Inflammation increases CD38 and decreases NAD. In addition, senescent cells and their secreted signals promote accumulation of CD38 cells in WAT, and ablation of senescent cells or their secretory phenotype decreases CD38, partially reversing NAD decline. Finally, blocking the ecto-enzymatic activity of CD38 can increase NAD through a nicotinamide mononucleotide (NMN)-dependent process. Our findings demonstrate that senescence-induced inflammation promotes accumulation of CD38 in immune cells that, through its ecto-enzymatic activity, decreases levels of NMN and NAD.</p> },
  year = {2020},
  journal = {Nat Metab},
  volume = {2},
  pages = {1284-1304},
  month = {2020 Nov},
  issn = {2522-5812},
  doi = {10.1038/s42255-020-00298-z},
  language = {eng},
}