@article{3921, keywords = {Quorum Sensing, Dose-Response Relationship, Drug, Microbial Sensitivity Tests, Bacterial Proteins, Protein Kinases, Staphylococcus aureus, Ligands, Peptides, Molecular Conformation}, author = {Qian Xie and Mareike Wiedmann and Aishan Zhao and Ivelisse Pagan and Richard Novick and Hiroaki Suga and Tom Muir}, title = {Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the receptor histidine kinase, AgrC.}, abstract = {

We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.

}, year = {2020}, journal = {Chem Commun (Camb)}, volume = {56}, pages = {11223-11226}, month = {2020 Sep 24}, issn = {1364-548X}, doi = {10.1039/d0cc04873a}, language = {eng}, }