@article{3736,
  keywords = {Animals, Disease Models, Animal, Mice, Humans, Macaca mulatta, Guinea Pigs, Rabbits, United States, Hepatitis B virus, Hepatitis B, Mycobacterium tuberculosis, Coinfection, HIV Infections, HIV-1, Marmota, National Institute of Allergy and Infectious Diseases (U.S.), Tuberculosis},
  author = {Ramesh Akkina and Daniel Barber and Moses Bility and Karl-Dimiter Bissig and Benjamin Burwitz and Katrin Eichelberg and Janice Endsley and J Victor Garcia and Richard Hafner and Petros Karakousis and Brent Korba and Rajen Koshy and Chris Lambros and Stephan Menne and Eric Nuermberger and Alexander Ploss and Brendan Podell and Larisa Poluektova and Brigitte Sanders-Beer and Selvakumar Subbian and Angela Wahl},
  title = {Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop.},
  abstract = { <p>The main advantage of animal models of infectious diseases over in vitro studies is the gain in the understanding of the complex dynamics between the immune system and the pathogen. While small animal models have practical advantages over large animal models, it is crucial to be aware of their limitations. Although the small animal model at least needs to be susceptible to the pathogen under study to obtain meaningful data, key elements of pathogenesis should also be reflected when compared to humans. Well-designed small animal models for HIV, hepatitis viruses and tuberculosis require, additionally, a thorough understanding of the similarities and differences in the immune responses between humans and small animals and should incorporate that knowledge into the goals of the study. To discuss these considerations, the NIAID hosted a workshop on {\textquoteright}Small Animal Models for HIV, Hepatitis B, and Tuberculosis{\textquoteright} on May 30, 2019. Highlights of the workshop are outlined below.</p> },
  year = {2020},
  journal = {Curr HIV Res},
  volume = {18},
  pages = {19-28},
  month = {2020},
  issn = {1873-4251},
  doi = {10.2174/1570162X18666191223114019},
  language = {eng},
}