@article{3622,
  keywords = {Biofilms, Anti-Bacterial Agents, Bacteria, Microbial Viability, Drug Tolerance, Drug Resistance, Bacterial},
  author = {Jing Yan and Bonnie Bassler},
  title = {Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms.},
  abstract = { <p>Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and~how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development.</p> },
  year = {2019},
  journal = {Cell Host Microbe},
  volume = {26},
  pages = {15-21},
  month = {2019 Jul 10},
  issn = {1934-6069},
  doi = {10.1016/j.chom.2019.06.002},
  language = {eng},
}