@article{3347,
  keywords = {Models, Biological, Cell Membrane, Cell Shape, Cell Polarity, Diffusion, Intracellular Space},
  author = {Rocky Diegmiller and Hadrien Montanelli and Cyrill Muratov and Stanislav Shvartsman},
  title = {Spherical Caps in Cell Polarization.},
  abstract = { <p>Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.</p> },
  year = {2018},
  journal = {Biophys J},
  volume = {115},
  pages = {26-30},
  month = {2018 Jul 03},
  issn = {1542-0086},
  doi = {10.1016/j.bpj.2018.05.033},
  language = {eng},
}