@article{3314,
  keywords = {Animals, Selection, Genetic, Epistasis, Genetic, Fishes, Evolution, Molecular, Hybridization, Genetic, Alleles, Chimera, Recombination, Genetic},
  author = {Molly Schumer and Chenling Xu and Daniel Powell and Arun Durvasula and Laurits Skov and Chris Holland and John Blazier and Sriram Sankararaman and Peter Andolfatto and Gil Rosenthal and Molly Przeworski},
  title = {Natural selection interacts with recombination to shape the evolution of hybrid genomes.},
  abstract = { <p>To investigate the consequences of hybridization between species, we studied three replicate hybrid populations that formed naturally between two swordtail fish species, estimating their fine-scale genetic map and inferring ancestry along the genomes of 690 individuals. In all three populations, ancestry from the "minor" parental species is more common in regions of high recombination and where there is linkage to fewer putative targets of selection. The same patterns are apparent in a reanalysis of human and archaic admixture. These results support models in which ancestry from the minor parental species is more likely to persist when rapidly uncoupled from alleles that are deleterious in hybrids. Our analyses further indicate that selection on swordtail hybrids stems predominantly from deleterious combinations of epistatically interacting alleles.</p> },
  year = {2018},
  journal = {Science},
  volume = {360},
  pages = {656-660},
  month = {2018 May 11},
  issn = {1095-9203},
  doi = {10.1126/science.aar3684},
  language = {eng},
}