@article{3307,
  keywords = {Animals, Caenorhabditis elegans, Signal Transduction, Animals, Genetically Modified, Cognitive Dysfunction, Cyclic AMP Response Element-Binding Protein, GTP-Binding Protein alpha Subunits, Gq-G11, Memory Consolidation},
  author = {Rachel Arey and Geneva Stein and Rachel Kaletsky and Amanda Kauffman and Coleen Murphy},
  title = {Activation of G Signaling Enhances Memory Consolidation and Slows Cognitive Decline.},
  abstract = { <p>Perhaps the most devastating decline with age is the~loss of memory. Therefore, identifying mechanisms to restore memory function with age is critical. Using C.~elegans associative learning and memory assays, we identified a gain-of-function G signaling pathway mutant that forms a long-term (cAMP response element binding protein [CREB]-dependent) memory following one conditioned stimulus-unconditioned stimulus (CS-US) pairing, which usually requires seven CS-US pairings. Increased CREB activity in AIM interneurons reduces the threshold for memory consolidation through transcription of a set of previously identified "long-term memory" genes. Enhanced G signaling in the AWC sensory neuron is both necessary and sufficient for improved memory and increased AIM CREB activity, and activation of G specifically in~aged animals rescues the ability to form memory. Activation of G in AWC sensory neurons non-cell autonomously induces consolidation after one CS-US pairing, enabling both cognitive function maintenance with age and restoration of memory function in animals with impaired memory performance without decreased longevity.</p> },
  year = {2018},
  journal = {Neuron},
  volume = {98},
  pages = {562-574.e5},
  month = {2018 May 02},
  issn = {1097-4199},
  doi = {10.1016/j.neuron.2018.03.039},
  language = {eng},
}