@article{3298,
  keywords = {Molecular Structure, Chromatography, Liquid, Tandem Mass Spectrometry, Peptides, Rotaxanes},
  author = {Hader Elashal and Ryan Cohen and Heidi Elashal and Chuhan Zong and A James Link and Monika Raj},
  title = {Cyclic and Lasso Peptides: Sequence Determination, Topology Analysis, and Rotaxane Formation.},
  abstract = { <p>A broadly applicable chemical cleavage methodology to facilitate MS/MS sequencing was developed for macrocyclic and lasso peptides, which hold promise as exciting new therapeutics. Existing methods such as Edman degradation, CNBr cleavage, and enzymatic digestion are either limited in scope or completely fail in cleavage of constrained nonribosomal peptides. Importantly, the new method was utilized for synthesizing a unique peptide-based rotaxane (both cyclic and threaded) from the lasso peptide, benenodin-1 ΔC5.</p> },
  year = {2018},
  journal = {Angew Chem Int Ed Engl},
  volume = {57},
  pages = {6150-6154},
  month = {2018 May 22},
  issn = {1521-3773},
  doi = {10.1002/anie.201801299},
  language = {eng},
}