@article{2321,
  keywords = {Quorum Sensing, Pseudomonas aeruginosa, Vibrio cholerae, Humans, Bacillus cereus, Bacterial Infections, Gene Expression Regulation, Staphylococcus aureus, Virulence Factors},
  author = {Steven Rutherford and Bonnie Bassler},
  title = {Bacterial quorum sensing: its role in virulence and possibilities for its control.},
  abstract = { <p>Quorum sensing is a process of cell-cell communication that allows bacteria to share information about cell density and adjust gene expression accordingly. This process enables bacteria to express energetically expensive processes as a collective only when the impact of those processes on the environment or on a host will be maximized. Among the many traits controlled by quorum sensing is the expression of virulence factors by pathogenic bacteria. Here we review the quorum-sensing circuits of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa, and Vibrio cholerae. We outline these canonical quorum-sensing mechanisms and how each uniquely controls virulence factor production. Additionally, we examine recent efforts to inhibit quorum sensing in these pathogens with the goal of designing novel antimicrobial therapeutics.</p> },
  year = {2012},
  journal = {Cold Spring Harb Perspect Med},
  volume = {2},
  month = {2012 Nov 01},
  issn = {2157-1422},
  doi = {10.1101/cshperspect.a012427},
  language = {eng},
}