@article{2302, keywords = {Pseudomonas aeruginosa, Amides, Anti-Bacterial Agents, Dose-Response Relationship, Drug, Microbial Sensitivity Tests, Molecular Structure, Pyocyanine, Pyridines, Small Molecule Libraries, Structure-Activity Relationship}, author = {Laura Miller and Colleen O{\textquoteright}Loughlin and Zinan Zhang and Albert Siryaporn and Justin Silpe and Bonnie Bassler and Martin Semmelhack}, title = {Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa.}, abstract = {

The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor produced by P. aeruginosa. Interestingly, these new antagonists appear to suppress P. aeruginosa virulence factor production through a pathway that is independent of LasR and RhlR.

}, year = {2015}, journal = {J Med Chem}, volume = {58}, pages = {1298-306}, month = {2015 Feb 12}, issn = {1520-4804}, doi = {10.1021/jm5015082}, language = {eng}, }