MOL 430 Power and Peril of Cycling Cells**
This class will focus on two central issues in cell biology: cell cycle and cell death. We begin with a mechanistic examination of the cell cycle in bacteria, yeast, flies, and mammals, focusing on cyclins and cyclin-dependent kinases. We then consider cell cycle exit, cell cycle and cell size, signaling pathways that regulate the cell cycle, and the cell cycles of transformed cells and stem cells. Cell death topics include the initiation, execution, and regulation of cell death in worms, flies, and mammals. We will emphasize biochemical and structural biology-based mechanisms of cell death, and the pathways that impinge on cell death.