Gavis Lab

Gavis lab research
Principal Investigator
Elizabeth R. Gavis
RNA localization and translational regulation during development in Drosophila

Localization of proteins to particular regions of cells or tissues is fundamental to the generation of asymmetry during development and the polarization of differentiated cells like neurons. In many cell types, protein synthesis can be targeted to sites where proteins are needed through the localization of their mRNAs. Furthermore, coupling of mRNA localization to translational control restricts protein synthesis to the target destination. Our lab studies the cellular and biochemical mechanisms of mRNA localization and localization-dependent translational control during oogenesis, embryogenesis, and neural development in Drosophila melanogaster.